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Viele Wissenschaftler sind allerdings der Meinung, dass mehr Forschung zu diesem Thema erforderlich ist.
Auszug aus Molina et al.: No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection.
Auszug aus Science Integrity Digest: Thoughts on the Gautret et al. paper about Hydroxychloroquine and Azithromycin treatment of COVID-19 infections:
The patients were recruited at different “centers”, but it is not very clear which patient was located in which hospital. The HQ treated patients were all in Marseille, while the controls were located in Marseille or other centers. One can imagine that hospitals might differ in treatment plans, ward layouts, availability of staff, disinfection routines, etc. It is not clear if controls and treated patients were all recruited and treated at the same hospital?
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So 4 of the 26 treated patients were actually not recovering at all. It seems a bit strange to leave these 4 patients who got worse or who died out of the study, just on the basis that they stopped taking the medication (which is pretty difficult once the patient is dead). As several people wrote sarcastically on Twitter: My results always look amazing if I leave out the patients who died, or the experiments that did not work.
Auszug aus dem posteinem post-publication review von Frits Rosendaal:
The index group and control group were drawn from different centres. The information that is given about characteristics of index group and control group is minimal, and still major differences are evident from all three variables shown (age, sex, presence of symptoms). The authors have performed statistical tests on these baseline characteristics, which is inappropriate. In the text they emphasise the absence of statistically significant differences between groups, implying that absence of statistical significance proves equality, which shows a lack of understanding of basic statistics.
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Auszug aus NDR: Drosten kritisiert Chloroquin-Studie:
Auszug aus Toumi & Aballea: Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al.
Auszug aus: Expressis-Verbis: Professor Didier Raoult, Sinnbild eines Widerstands französischer Prägung