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  • For the case of 1:10, 1:1 and 1:200 of protein:ligand fractions, in 035, 035...LessOfLigand and 035...MoreOfLigand.
  • Check the simulated NOESY spectra (!note that the axes are not chemical shifts but simply atomic indices!)
    • see the file: NOESYZoomLigand.pdf, the right lower corner is the section corresponding to the ligand.
  • How would you determine structure of a ligand in the bound stateWhat more is not realistic about this simulation?


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  • We check the effect of the exchange rate on the resulting cross-relaxation rates.
    See e.g. like: tail -n 15 outputKex5e*
  • What would be the consequence of "not so fast" exchange?
  • run ./proteinLigandCalcNOESY.py triPepMod.pdb
    • experiment with settings in parameters*.json files.

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