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  • Look at the coordinates (3 and 2 atoms extracted from a protein structure)
    • cd ~/038_toySystemWeightIntermolecularNoes
    • cat triPepMod.pdb
  • Print the content of the file on the screen 
    • cat NOESYwhenDifferentExchangeRates.txt

    • (or you can extract these using: grep -A 5 "NOESY intensities s" outputKex5e*t10)

  •  Look at the last column, last two rows, corresponding to the ligand NOE signals and note their intensity for different exchange frequencies - between 5 Hz and 5 MHz
  • What would be the consequence of "not so fast" exchange?
    1. for ligand structure calculation
    2. protein structure calculation
    3. protein-ligand distance extraction?
  • experiment by modifying the parameters in parametersForKinMatrixDict.json (open in some text editor, such as vim)
  • run ./proteinLigandCalcNOESY.py triPepMod.pdb

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